Indications A-Z

RxReasoner presents a comprehensive list of pharmaceutical treatment indications drawn from medicine package inserts issued by authoritative regulatory bodies globally.

This index serves as a valuable tool to quickly access information on the recommended therapeutic approaches for different medical conditions, diseases or symptoms.

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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Indications starting with 'D'

Indication Treatments
Decompensated cardiac failure
Dobutamine : Cardiac decompensation, disturbed ventricular function – only minors (0 - 18 years old)
Dobutamine : Cardiac decompensation, disturbed ventricular function – only adults (18 years old or older)
Decompensated chronic heart failure
Levosimendan : Acutely decompensated chronic heart failure (ADHF) – only adults (18 years old or older)
Decreased carbohydrate
Glucose : Carbohydrate depletion, fluid depletion – only minors (0 - 18 years old) , adults (18 years old or older)
Deep mycosis
Posaconazole : Refractory invasive fungal infections (IFI) – only adults (18 years old or older)
Deep venous thrombosis
Bemiparin : Deep vein thrombosis – only adults (18 years old or older)
Dabigatran : Deep vein thrombosis and pulmonary embolism – only adults (18 years old or older)
Dabigatran : Recurrent deep vein thrombosis and pulmonary embolism – only adults (18 years old or older)
Enoxaparin : Deep vein thrombosis (DVT), pulmonary embolism (PE) – only adults (18 years old or older)
Heparin : Deep vein thrombosis – only children (1 year - 12 years old) , adolescents (12 years - 18 years old)
Heparin : Deep vein thrombosis – only adults (18 years old or older)
Nadroparin : Deep venous thrombosis, pulmonary embolism – only adults (18 years old or older)
Rivaroxaban : Deep vein thrombosis (DVT), pulmonary embolism (PE) – only adults (18 years old or older)
Deficiency of mevalonate kinase
Canacinumab : Hyperimmunoglobulin D syndrome (HIDS), mevalonate kinase deficiency (MKD) – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Deficiency of phosphoenolpyruvate kinase
Mitapivat : Pyruvate kinase deficiency (PK deficiency) – only adults (18 years old or older)
Deficiency of tryptophan decarboxylase
Eladocagene exuparvovec : Aromatic L-amino acid decarboxylase (AADC) deficiency with a severe phenotype – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Delayed puberty
Chorionic gonadotrophin (human) : Delayed puberty – men, only adolescents (12 years - 18 years old)
Deliberate self-harm
Lithium : Aggressive behaviour, self mutilating behaviour – only adults (18 years old or older)
Delirium
Haloperidol : Delirium – only elderly (65 years old or older)
Haloperidol : Delirium – only adults (18 - 65 years old)
Delta-4-3-oxosteroid-5-beta-reductase deficiency
Cholic acid : Δ<sup>4</sup>-3-Oxosteroid-5β-reductase deficiency – only adults (18 - 65 years old)
Dementia associated with Parkinson's Disease
Rivastigmine : Mild to moderately severe dementia with idiopathic Parkinson's disease – only adults (18 years old or older)
Dental surgical procedure
Hexetidine : Mouth infections, gingivitis, sore throat, aphthous ulcer, halitosis, dental surgery – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Depressive disorder
Citalopram : Depression – only adults (18 - 65 years old)
Citalopram : Depression – only elderly (65 years old or older)
Clomipramine : Depressive illness – only adults (18 years old or older)
Doxepin : Depression – only adults (18 years old or older)
Maprotiline : Depression – only adults (18 years old or older)
Trazodone : Depression – only elderly (65 years old or older)
Trazodone : Depression – only adults (18 - 65 years old)
Dermabrasion
Dexpanthenol : Superficial skin lesion, skin inflammation
Dermal mycosis
Clotrimazole : Dermal mycosis
Dermatitis herpetiformis
Dapsone : Dermatitis herpetiformis – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Dermatofibrosarcoma protuberans
Imatinib : Dermatofibrosarcoma protuberans (DFSP) – only adults (18 years old or older)
Dermatographic urticaria
Dexchlorpheniramine : Perennial and seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis, urticaria, angioedema
Dermatomyositis
Azathioprine : Auto-immune disorders – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Methylprednisolone : Dermatomyositis – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Prednisolone : Dermatomyositis – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Dermatophytosis
Econazole : Dermatophytosis – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Miconazole : Mycotic infections of the skin and nails – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Dermatosis of scalp
Clobetasol propionate : Recalcitrant dermatoses – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Diabetes insipidus
Chlortalidone : Diabetes insipidus – only children (1 year - 12 years old) , adolescents (12 years - 18 years old)
Chlortalidone : Diabetes insipidus – only adults (18 years old or older)
Hydrochlorothiazide : Diabetes insipidus – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Diabetes mellitus
Insulin (human) : Diabetes mellitus – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Insulin aspart : Diabetes mellitus – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Insulin detemir : Diabetes mellitus – men, only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Insulin glargine : Diabetes mellitus – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 - 65 years old)
Insulin glulisine : Diabetes mellitus – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Insulin lispro : Diabetes mellitus – only adults (18 years old or older)
Diabetes mellitus type 2 in obese
Acarbose : Diabetes mellitus – only adults (18 years old or older)
Rimonabant : Obese associated type 2 diabetes – only adults (18 years old or older)
Diabetes mellitus type I
Insulin degludec : Diabetes mellitus type 2 – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Sotagliflozin : Diabetes mellitus type 1 – only adults (18 years old or older)
Diabetes mellitus type II
Alogliptin : Diabetes mellitus type 2 – only adults (18 years old or older)
Canagliflozin : Diabetes mellitus type 2 – only adults (18 years old or older)
Dapagliflozin : Diabetes mellitus type 2 – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Dulaglutide : Type 2 diabetes mellitus – only adults (18 years old or older)
Empagliflozin : Diabetes mellitus type 2 – only adults (18 years old or older)
Ertugliflozin : Diabetes mellitus type 2 – only adults (18 years old or older)
Exenatide : Diabetes mellitus type 2 – only adults (18 years old or older)
Glibenclamide : Diabetes mellitus – only adults (18 years old or older)
Gliclazide : Non insulin dependent diabetes mellitus type 2 – only adults (18 years old or older)
Glimepiride : Diabetes mellitus type 2 – only adults (18 years old or older)
Insulin degludec : Diabetes mellitus type 2 – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Liraglutide : Diabetes mellitus type 2 – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Lixisenatide : Diabetes mellitus type 2 – only adults (18 years old or older)
Luseogliflozin : Diabetes mellitus type 2 – only adults (18 years old or older)
Metformin : Type 2 diabetes mellitus – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Nateglinide : Diabetes mellitus type 2 – only adults (18 - 65 years old)
Pioglitazone : Diabetes mellitus type 2 – only adults (18 years old or older)
Repaglinide : Diabetes mellitus type 2 – only adults (18 - 65 years old)
Rosiglitazone : Diabetes mellitus type 2 – only adults (18 years old or older)
Saxagliptin : Diabetes mellitus type 2 – only adults (18 years old or older)
Semaglutide : Diabetes mellitus type 2 – only adults (18 - 65 years old)
Sitagliptin : Diabetes mellitus type 2 – only adults (18 years old or older)
Teneligliptin : Type 2 diabetes mellitus – only adults (18 years old or older)
Tirzepatide : Insufficiently controlled type 2 diabetes mellitus – only adults (18 years old or older)
Vildagliptin : Diabetes mellitus type 2 – only adults (18 years old or older)
Diabetic macular edema
Aflibercept : Visual impairment due to diabetic macular oedema (DME) – only adults (18 years old or older)
Dexamethasone : Diabetic macular edema (DME) – only adults (18 years old or older)
Faricimab : Visual impairment due to diabetic macular oedema (DME) – only adults (18 years old or older)
Diabetic peripheral neuropathy
Duloxetine : Diabetic peripheral neuropathic pain – only adults (18 years old or older)
Diaper rash
Clobetasone : Atopic dermatitis, irritant or allergic contact dermatitis, seborrhoeic dermatitis, nappy rash, photodermatitis – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Hydrocortisone : Prurigo nodularis, neurodermatoses, otitis externa, intertrigo, napkin rash – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Diarrhea
Codeine : Diarrhoea – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Methylcellulose : Colostomy, ileostomy, diarrhoea – only adults (18 years old or older)
Opium : Diarrhoea – only adults (18 - 65 years old)
Diffuse malignant lymphoma - histiocytic
Axicabtagene ciloleucel : Relapsed or refractory diffuse large B-cell lymphoma (DLBCL) – only adults (18 - 65 years old)
Epcoritamab : Relapsed or refractory diffuse large B-cell lymphoma – only adults (18 years old or older)
Glofitamab : Relapsed or refractory diffuse large B-cell lymphoma – only adults (18 years old or older)
Lisocabtagene maraleucel : Relapsed or refractory diffuse large B-cell lymphoma (DLBCL) – only adults (18 years old or older)
Loncastuximab tesirine : Diffuse large B-cell lymphoma (DLBCL), high-grade B-cell lymphoma (HGBL) – only adults (18 years old or older)
Polatuzumab vedotin : Diffuse large B-cell lymphoma (DLBCL) – only adults (18 years old or older)
Rituximab : Diffuse large B cell non-Hodgkin's lymphoma – only adults (18 years old or older)
Tafasitamab : Diffuse large B-cell lymphoma (DLBCL) – only adults (18 years old or older)
Diffuse spasm of esophagus
Butylscopolamine : Spasm, endoscopy of the genito-urinary tract or gastro- intestinal tract, Irritable Bowel Syndrome – only children (1 year - 12 years old)
Butylscopolamine : Spasm, endoscopy of the genito-urinary tract or gastro- intestinal tract, Irritable Bowel Syndrome – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Dilation of cervical canal
Mifepristone : Softening and dilatation of the cervix uteri prior to surgical termination of pregnancy during the first trimester – women, only adults (18 - 65 years old)
Diphtheria caused by Corynebacterium diphtheriae
Benzylpenicillin : Diphtheria – only newborns (0 - 40 days old)
Benzylpenicillin : Diphtheria – only infants (40 days - 1 year old) , children (1 year - 12 years old)
Benzylpenicillin : Diphtheria – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Direct current atrial defibrillation
Sotalol : Maintenance of normal sinus rhythm following conversion of atrial fibrillation or atrial flutter – only adults (18 years old or older)
Discoid lupus erythematosus
Betamethasone : Discoid lupus erythematosus – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Fluocinonide : Discoid lupus erythematosus – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Hydroxychloroquine : Juvenile idiopathic arthritis, discoid and systemic lupus erythematosus – only children (1 year - 12 years old) , adolescents (12 years - 18 years old)
Hydroxychloroquine : Rheumatoid arthritis, discoid and systemic lupus erythematosus, sunlight damaged skin – only adults (18 years old or older)
Disease caused by 2019 novel coronavirus
Bamlanivimab : Mild-to-moderate COVID-19 – only adolescents (12 years - 18 years old)
Bamlanivimab : Mild-to-moderate COVID-19 – only adults (18 years old or older)
Molnupiravir : Mild to moderate coronavirus disease 2019 (COVID-19) – only adults (18 - 65 years old)
Regdanvimab : Coronavirus disease 2019 (COVID-19) – only adults (18 years old or older)
Sotrovimab : Coronavirus disease 2019 (COVID-19) who do not require oxygen supplementation – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Disease caused by Gram-positive bacteria
Floxacillin : Infections – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Disinfection of skin
Ethanol : Disinfection of skin – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Disorder of musculoskeletal system
Naproxen : Musculoskeletal disorders – only adults (18 years old or older)
Disorder of the urea cycle metabolism
Glycerol phenylbutyrate : Urea cycle disorders (UCDs) – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 - 65 years old)
Sodium phenylbutyrate : Urea cycle disorders – only newborns (0 - 40 days old) , infants (40 days - 1 year old)
Sodium phenylbutyrate : Urea cycle disorders – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 - 65 years old)
Disorders of skin induced by physical agents
Dexpanthenol : Superficial skin lesion, skin inflammation
Dissection of aorta
Nicardipine : Malignant hypertension, hypertensive encephalopathy, dissection of aorta, postoperative hypertension – only elderly (65 years old or older)
Nicardipine : Malignant hypertension, hypertensive encephalopathy, dissection of aorta, severe pre-eclampsia, postoperative hypertension – only adults (18 - 65 years old)
Disseminated candidiasis
Anidulafungin : Invasive candidiasis – only adults (18 years old or older)
Caspofungin : Invasive candidiasis – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old)
Caspofungin : Invasive candidiasis – only adults (18 years old or older)
Fluconazole : Invasive candidiasis – only newborns (0 - 40 days old)
Fluconazole : Invasive candidiasis – only infants (40 days - 1 year old) , children (1 year - 12 years old)
Fluconazole : Invasive candidiasis – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Micafungin : Invasive candidiasis – only newborns (0 - 40 days old) , infants (40 days - 1 year old)
Micafungin : Invasive candidiasis – only children (1 year - 12 years old)
Micafungin : Invasive candidiasis – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Rezafungin : Invasive candidiasis – only adults (18 years old or older)
Voriconazole : Invasive Candida infection – only children (1 year - 12 years old)
Voriconazole : Invasive Candida infection – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Disseminated Lyme borreliosis
Ceftriaxone : Disseminated Lyme borreliosis (early [Stage II] and late [Stage III]) – only infants (40 days - 1 year old) , children (1 year - 12 years old)
Ceftriaxone : Disseminated Lyme borreliosis (early [Stage II] and late [Stage III]) – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Disseminated tuberculosis
Methylprednisolone : Disseminated tuberculosis – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old)
Methylprednisolone : Disseminated tuberculosis – only adults (18 years old or older)
Diverticular disease
Atropine : Diverticular disease – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Methylcellulose : Diverticular disease, ulcerative colitis – only adults (18 years old or older)
Doppler ultrasonography
Sulfur hexafluoride : Doppler sonography – only adults (18 years old or older)
Doppler ultrasonography of blood vessel
Sulfur hexafluoride : Doppler ultrasonography of blood vessel – only adults (18 years old or older)
Drug induced gastric ulcer
Esomeprazole : NSAID associated benign gastric and duodenal ulcers – only adults (18 years old or older)
Lansoprazole : NSAID associated benign gastric and duodenal ulcers – only adults (18 years old or older)
Omeprazole : Non-steroidal anti-inflammatory drug associated gastric and duodenal ulcers – only adults (18 years old or older)
Ranitidine : Ulcers following NSAID therapy or associated with continued NSAIDs – only adults (18 years old or older)
Drug reaction
Promethazine : Allergic rhinitis, urticaria, anaphylactic reactions to drugs – only children (1 year - 12 years old)
Promethazine : Allergic rhinitis, urticaria, anaphylactic reactions to drugs – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Drug treatment to delay menstruation
Norethisterone : Postponement of menstruation – women, only adults (18 - 65 years old)
Drug-aggravated angio-oedema-urticaria
Acetazolamide : Congestive heart failure oedema, drug induced oedema – only adults (18 years old or older)
Drug-induced hyperprolactinaemia
Bromocriptine : Drug-induced hyperprolactinaemic disorders – only adults (18 years old or older)
Drug-induced methemoglobinemia
Methylthioninium chloride : Drug induced methaemoglobinaemia – only newborns (0 - 40 days old)
Methylthioninium chloride : Drug induced methaemoglobinaemia – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Drug-induced peptic ulcer
Misoprostol : Prophylaxis of NSAID-induced ulcers – only adults (18 years old or older)
Dry cornea
Hypromellose : Dehydration of the cornea and conjunctiva – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Dry cough
Butamirate : Dry cough – only adults (18 years old or older)
Butamirate : Dry cough – only children (1 year - 12 years old)
Butamirate : Dry cough – only adolescents (12 years - 18 years old)
Codeine : Dry cough – only adults (18 years old or older)
Diphenhydramine : Non-productive cough – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Pholcodine : Non-productive, dry cough – only children (1 year - 12 years old)
Dry eyes
Carbomer : Dry eye – only adults (18 years old or older)
Carmellose : Dry eye – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Hypromellose : Dehydration of the cornea and conjunctiva – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Polyvidone : Dry eye
Dry skin
Glycerol : Dry skin – only children (1 year - 12 years old)
Glycerol : Dry skin – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Duchenne muscular dystrophy
Ataluren : Duchenne muscular dystrophy – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Vamorolone : Duchenne muscular dystrophy – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Duodenal ulcer caused by Helicobacter pylori
Ranitidine : Duodenal ulcers associated with Helicobacter pylori infection – only adults (18 years old or older)
Duodenal ulcer caused by non-steroidal anti-inflammatory drug
Esomeprazole : NSAID associated benign gastric and duodenal ulcers – only adults (18 years old or older)
Lansoprazole : NSAID associated benign gastric and duodenal ulcers – only adults (18 years old or older)
Omeprazole : Non-steroidal anti-inflammatory drug associated gastric and duodenal ulcers – only adults (18 years old or older)
Duodenal ulcer disease
Cimetidine : Duodenal ulceration, gastric ulceration – only children (1 year - 12 years old) , adolescents (12 years - 18 years old)
Cimetidine : Duodenal ulceration, gastric ulceration – only infants (40 days - 1 year old)
Cimetidine : Duodenal ulceration, gastric ulceration – only adults (18 years old or older)
Famotidine : Duodenal ulcer – only adults (18 years old or older)
Lansoprazole : Duodenal ulcer – only adults (18 years old or older)
Misoprostol : Duodenal ulcer, gastric ulcer – only adults (18 years old or older)
Nizatidine : Duodenal ulcer – only adults (18 years old or older)
Omeprazole : Duodenal ulcer – only adults (18 years old or older)
Rabeprazole : Active duodenal ulcer, active benign gastric ulcer – only adults (18 years old or older)
Ranitidine : Duodenal ulcer, benign gastric ulcer – only children (1 year - 12 years old)
Ranitidine : Duodenal ulcer, benign gastric ulcer – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Sucralfate : Duodenal ulcer, chronic gastritis, peptic esophagitis – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Tripotassium dicitrato bismuthate : Gastric ulcer, duodenal ulcer – only adults (18 years old or older)
Dupuytren's disease of palm
Collagenase : Dupuytren's contracture – only adults (18 years old or older)
Dyslipidemia
Alirocumab : Primary heterozygous familial hypercholesterolaemia, primary non-familial hypercholesterolaemia, mixed dyslipidaemia – only adults (18 years old or older)
Evolocumab : Primary hypercholesterolaemia (heterozygous familial and non-familial), mixed dyslipidaemia – only adults (18 years old or older)
Fluvastatin : Primary hypercholesterolaemia, mixed dyslipidaemia – only adults (18 years old or older)
Pemafibrate : Dyslipidemia characterised by high TG ≥150 mg/dL – only adults (18 years old or older)
Pitavastatin : Primary hypercholesterolaemia, mixed dyslipidaemia – only adults (18 years old or older)
Pravastatin : Primary hypercholesterolaemia, mixed dyslipidaemia – only adults (18 years old or older)
Rosuvastatin : Primary hypercholesterolaemia, mixed dyslipidaemia – only elderly (65 years old or older)
Rosuvastatin : Primary hypercholesterolaemia, mixed dyslipidaemia – only adults (18 - 65 years old)
Simvastatin : Primary hypercholesterolemia, mixed dyslipidaemia – only adults (18 years old or older)
Dyssomnia
Diphenhydramine : Sleep disturbance – only adults (18 years old or older)
Valerian : Sleep disturbances – only adults (18 years old or older)

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