Indications A-Z

RxReasoner presents a comprehensive list of pharmaceutical treatment indications drawn from medicine package inserts issued by authoritative regulatory bodies globally.

This index serves as a valuable tool to quickly access information on the recommended therapeutic approaches for different medical conditions, diseases or symptoms.

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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Indications starting with 'M'

Indication Treatments
Magnesium deficiency
Magnesium aspartate : Magnesium deficiency – only children (1 year - 12 years old)
Magnesium aspartate : Magnesium deficiency – only adolescents (12 years - 18 years old)
Magnesium aspartate : Magnesium deficiency – only adults (18 years old or older)
Magnetic resonance imaging
Gadoteridol : Magnetic Resonance Imaging (MRI) – only children (1 year - 12 years old) , adolescents (12 years - 18 years old)
Gadoteridol : Magnetic Resonance Imaging (MRI) – only adults (18 years old or older)
Mangafodipir : Magnetic resonance imaging – only adults (18 years old or older)
Magnetic resonance imaging of brain and brain stem
Gadoversetamide : Magnetic resonance imaging (MRI) of the central nervous system (CNS) and liver – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Magnetic resonance imaging of kidney with contrast
Gadobutrol : Magnetic resonance imaging (MRI) of liver or kidneys – only minors (0 - 18 years old) , adults (18 years old or older)
Magnetic resonance imaging of liver with contrast
Gadobenic acid : Magnetic resonance imaging of liver with contrast – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Gadobutrol : Magnetic resonance imaging (MRI) of liver or kidneys – only minors (0 - 18 years old) , adults (18 years old or older)
Gadopiclenol : Magnetic resonance imaging – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Gadoversetamide : Magnetic resonance imaging (MRI) of the central nervous system (CNS) and liver – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Gadoxetic acid : Magnetic resonance imaging of liver with contrast – only adults (18 years old or older)
Magnetic resonance imaging of musculoskeletal structures
Gadopiclenol : Magnetic resonance imaging – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Magnetic resonance imaging of prostate
Gadopiclenol : Magnetic resonance imaging – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Magnetic resonance imaging of whole body
Gadobutrol : Whole body magnetic resonance imaging (MRI) – only minors (0 - 18 years old) , adults (18 years old or older)
Gadoteric acid : Magnetic resonance imaging (MRI) of whole body – only minors (0 - 18 years old) , adults (18 years old or older)
Maintaining asepsis
Iodine : Antisepsis – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Maintenance of general anaesthesia
Desflurane : Induction and maintenance of general anaesthesia – only adults (18 years old or older)
Desflurane : Maintenance of general anaesthesia – only infants (40 days - 1 year old) , adolescents (12 years - 18 years old)
Isoflurane : Induction and maintenance of general anaesthesia – only adults (18 years old or older)
Ketamine : Induction of general anesthesia, maintenance of general anesthesia – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Propofol : Maintenance of anaesthesia – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Rocuronium : Facilitation of tracheal intubation to general anaesthesia – only minors (0 - 18 years old) , adults (18 years old or older)
Sevoflurane : Induction and maintenance of general anaesthesia – only minors (0 - 18 years old) , adults (18 years old or older)
Major depressive disorder
Agomelatine : Major depressive episodes – only adults (18 - 65 years old)
Amitriptyline : Major depressive disorder – only elderly (65 years old or older)
Amitriptyline : Major depressive disorder – only adults (18 - 65 years old)
Duloxetine : Major depressive disorder – only adults (18 years old or older)
Escitalopram : Major depressive episodes – only adults (18 years old or older)
Esketamine : Major depressive disorder – only elderly (65 years old or older)
Esketamine : Major depressive disorder – only adults (18 - 65 years old)
Fluoxetine : Major depressive episodes – only adults (18 years old or older)
Fluvoxamine : Major depressive episode – only adults (18 years old or older)
Mirtazapine : Episodes of major depression – only adults (18 years old or older)
Moclobemide : Major depression – only adults (18 years old or older)
Paroxetine : Major depressive episode – only adults (18 years old or older)
Quetiapine : Add-on treatment of major depressive episodes in patients with Major Depressive Disorder (MDD) – only elderly (65 years old or older)
Quetiapine : Add-on treatment of major depressive episodes in patients with Major Depressive Disorder (MDD) – only adults (18 years old or older)
Sertraline : Major depressive episodes – only adults (18 years old or older)
Sertraline : Major depressive episodes – only adults (18 years old or older)
Venlafaxine : Major depressive episodes – only adults (18 years old or older)
Venlafaxine : Recurrence of major depressive episodes – only adults (18 years old or older)
Vortioxetine : Major depressive episodes – only elderly (65 years old or older)
Vortioxetine : Major depressive episodes – only adults (18 - 65 years old)
Malaria
Artesunate : Severe malaria – only minors (0 - 18 years old) , adults (18 years old or older)
Male hypogonadism
Testosterone : Male hypogonadism – men, only adults (18 years old or older)
Male pattern alopecia
Minoxidil : Alopecia androgenetica in women – women, only adults (18 - 65 years old)
Male sterility
Chorionic gonadotrophin (human) : Sterility – men, only adults (18 - 65 years old)
Malignant ascites
Catumaxomab : Malignant ascites with EpCAM-positive carcinomas – only adults (18 years old or older)
Spironolactone : Malignant ascites – only adults (18 years old or older)
Malignant bone pain
Samarium ¹⁵³Sm lexidronam : Bone pain in osteoblastic skeletal metastases – only adults (18 years old or older)
Malignant epithelial tumor of ovary
Bevacizumab : Epithelial ovarian, fallopian tube and primary peritoneal cancer
Carboplatin : Advanced ovarian carcinoma of epithelial origin – women, only adults (18 years old or older)
Cis-Diaminedichloroplatinum : Ovary carcinoma – women, only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Gemcitabine : Epithelial ovarian carcinoma – women, only adults (18 years old or older)
Niraparib : Advanced epithelial high-grade ovarian, fallopian tube or primary peritoneal cancer – only adults (18 years old or older)
Niraparib : Platinum-sensitive relapsed high grade serous epithelial ovarian, fallopian tube, or primary peritoneal cancer – only adults (18 years old or older)
Rucaparib : Epithelial ovarian cancer, fallopian tube cancer, primary peritoneal cancer – only adults (18 years old or older)
Malignant glioma of brain
Temozolomide : Malignant glioma – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Malignant glioma of spinal cord
Temozolomide : Malignant glioma – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Malignant hypertension
Nicardipine : Malignant hypertension, hypertensive encephalopathy, dissection of aorta, postoperative hypertension – only elderly (65 years old or older)
Nicardipine : Malignant hypertension, hypertensive encephalopathy, dissection of aorta, severe pre-eclampsia, postoperative hypertension – only adults (18 - 65 years old)
Malignant lymphoma
22-Oxovincaleukoblastine : Malignant lymphomas – only adults (18 years old or older)
Methylprednisolone : Malignant lymphoma – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Prednisolone : Lymphoma – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Thiotepa : Malignant lymphoma – only adults (18 years old or older)
Malignant lymphoma, lymphocytic, well differentiated
Acalabrutinib : Small lymphocytic lymphoma – only adults (18 years old or older)
Malignant melanoma
Dacarbazine : Malignant melanoma – only adults (18 years old or older)
Interferon, alfa-2b : Malignant melanoma – only adults (18 years old or older)
Ipilimumab : Melanoma – only adults (18 years old or older)
Ipilimumab : Melanoma – only adolescents (12 years - 18 years old)
Melphalan : Malignant melanoma – only adults (18 years old or older)
Nivolumab : Melanoma – only adults (18 years old or older)
Pembrolizumab : Adjuvant treatment of Stage III melanoma and lymph node involvement – only adults (18 - 65 years old)
Talimogene laherparepvec : Melanoma – only adults (18 years old or older)
Malignant melanoma with B-Raf proto-oncogene, serine/threonine kinase V600E mutation
Binimetinib : Unresectable or metastatic melanoma with a BRAF V600 mutation – only adults (18 years old or older)
Cobimetinib : Metastatic melanoma with a BRAF V600 mutation – only adults (18 years old or older)
Encorafenib : Unresectable or metastatic melanoma with a BRAF V600 mutation – only adults (18 years old or older)
Trametinib : Melanoma with a BRAF V600 mutation – only adults (18 years old or older)
Trametinib : Stage III melanoma with a BRAF V600 mutation – only adults (18 years old or older)
Malignant mesothelioma of pleura
Pemetrexed : Malignant pleural mesothelioma – only adults (18 years old or older)
Malignant neoplasm of cardio-esophageal junction of stomach
Fluorouracil : Gastric cancer, cancer of gastroesophageal junction – only adults (18 years old or older)
Malignant neoplasm of central nervous system
Thiotepa : Malignant neoplasm of central nervous system – only children (1 year - 12 years old) , adolescents (12 years - 18 years old)
Thiotepa : Malignant neoplasm of central nervous system – only adults (18 years old or older)
Malignant neoplasm of skin
Fluorouracil : Pre-malignant and malignant skin lesions – only adults (18 years old or older)
Malignant tumor of breast
Capecitabine : Breast cancer – only adults (18 years old or older)
Docetaxel : Breast cancer – only adults (18 years old or older)
Doxorubicin : Breast cancer – only adults (18 years old or older)
Epirubicin : Carcinoma of the breast – only adults (18 years old or older)
Eribulin mesylate : Locally advanced or metastatic breast cancer – only adults (18 - 65 years old)
Fluorouracil : Breast cancer – only adults (18 years old or older)
Gemcitabine : Breast cancer – only adults (18 years old or older)
Leuprorelin : Breast cancer – only adults (18 years old or older)
Megestrol : Breast cancer – women, only adults (18 years old or older)
Mitomycin : Advanced and/or metastatic breast cancer – only adults (18 years old or older)
Mitoxantrone : Metastatic breast cancer – only adults (18 years old or older)
Tamoxifen : Breast cancer – only adults (18 years old or older)
Thiotepa : Breast cancer – only adults (18 years old or older)
Vinorelbine : Breast cancer – only adults (18 years old or older)
Malignant tumor of fallopian tube
Bevacizumab : Epithelial ovarian, fallopian tube and primary peritoneal cancer
Niraparib : Advanced epithelial high-grade ovarian, fallopian tube or primary peritoneal cancer – only adults (18 years old or older)
Niraparib : Platinum-sensitive relapsed high grade serous epithelial ovarian, fallopian tube, or primary peritoneal cancer – only adults (18 years old or older)
Rucaparib : Epithelial ovarian cancer, fallopian tube cancer, primary peritoneal cancer – only adults (18 years old or older)
Malignant tumor of head and neck
22-Oxovincaleukoblastine : Head and neck carcinoma – only adults (18 years old or older)
Malignant tumor of peritoneum
Bevacizumab : Epithelial ovarian, fallopian tube and primary peritoneal cancer
Niraparib : Advanced epithelial high-grade ovarian, fallopian tube or primary peritoneal cancer – only adults (18 years old or older)
Niraparib : Platinum-sensitive relapsed high grade serous epithelial ovarian, fallopian tube, or primary peritoneal cancer – only adults (18 years old or older)
Malignant tumor of stomach
Capecitabine : Gastric cancer – only adults (18 years old or older)
Epirubicin : Gastric cancer – only adults (18 years old or older)
Fluorouracil : Gastric cancer, cancer of gastroesophageal junction – only adults (18 years old or older)
Ramucirumab : Advanced gastric cancer, gastro-oesophageal junction adenocarcinoma – only adults (18 years old or older)
Malignant tumor of thyroid gland
Selpercatinib : RET fusion-positive thyroid cancer – only adults (18 years old or older)
Thyrotropin : Detection of thyroid remnants and well-differentiated thyroid cancer – only adults (18 years old or older)
Malignant tumour
Ifosfamide : Malignant neoplastic disease – only children (1 year - 12 years old) , adolescents (12 years - 18 years old)
Ifosfamide : Malignant neoplastic disease – only adults (18 years old or older)
Malignant tumour of cervix
Bevacizumab : Cervical Cancer
Malignant tumour of kidney
Bevacizumab : Advanced and/or metastatic renal cell cancer (mRCC)
Malignant tumour of oesophagus
Fluorouracil : Oesophageal cancer – only adults (18 years old or older)
Malignant tumour of ovary
Doxorubicin : Ovarian cancer – women, only adults (18 years old or older)
Epirubicin : Ovarian cancer – only adults (18 years old or older)
Etoposide : Ovarian cancer – women, only adults (18 years old or older)
Melphalan : Ovarian cancer – women, only adults (18 years old or older)
Thiotepa : Ovarian cancer – women, only adults (18 years old or older)
Malignant tumour of pancreas
Erlotinib : Metastatic pancreatic cancer – only adults (18 years old or older)
Fluorouracil : Pancreatic cancer – only adults (18 years old or older)
Malignant tumour of prostate
Bicalutamide : Prostate cancer – men, only adults (18 years old or older)
Cyproterone : Cancer of prostate – men, only adults (18 - 65 years old)
Flutamide : Prostatic carcinoma – men, only adults (18 years old or older)
Goserelin : Prostate cancer – men, only adults (18 years old or older)
Leuprorelin : Prostate cancer – men, only adults (18 years old or older)
Sipuleucel-T : Prostate cancer – men, only adults (18 years old or older)
Triptorelin : Prostate cancer – men, only adults (18 years old or older)
Malignant tumour of testis
Cis-Diaminedichloroplatinum : Testicular carcinoma – men, only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Etoposide : Testicular cancer – men, only adults (18 years old or older)
Malignant tumour of urinary bladder
Gemcitabine : Bladder cancer – only adults (18 years old or older)
Mania
Chlorpromazine : Schizophrenia, mania, hypomania – only elderly (65 years old or older)
Chlorpromazine : Schizophrenia, mania, hypomania – only adults (18 - 65 years old)
Lithium : Mania, hypomania – only adults (18 years old or older)
Manic bipolar I disorder
Aripiprazole : Manic episodes in Bipolar I Disorder – only adolescents (12 years - 18 years old)
Haloperidol : Moderate to severe manic episodes associated with bipolar I disorder – only elderly (65 years old or older)
Haloperidol : Moderate to severe manic episodes associated with bipolar I disorder – only adults (18 - 65 years old)
Risperidone : Moderate to severe manic episodes associated with bipolar disorders – only adults (18 - 65 years old)
Risperidone : Moderate to severe manic episodes associated with bipolar disorders – only elderly (65 years old or older)
Mannosidosis
Velmanase alfa : Mild to moderate alpha-mannosidosis – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 - 65 years old)
Mantle cell lymphoma
Acalabrutinib : Mantle cell lymphoma – only adults (18 years old or older)
Bortezomib : Mantle cell lymphoma – only adults (18 - 65 years old)
Ibrutinib : Relapsed or refractory mantle cell lymphoma (MCL) – only adults (18 years old or older)
Lenalidomide : Mantle cell lymphoma – only adults (18 - 65 years old)
Pirtobrutinib : Relapsed or refractory mantle cell lymphoma – only adults (18 years old or older)
Temsirolimus : Mantle cell lymphoma – only adults (18 years old or older)
Marginal keratitis
Dexamethasone : Marginal keratitis – only adults (18 years old or older)
Maroteaux-Lamy syndrome
Galsulfase : Mucopolysaccharidosis VI – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Mast cell leukemia (clinical)
Midostaurin : Aggressive systemic mastocytosis, systemic mastocytosis with associated haematological neoplasm, mast cell leukaemia – only adults (18 - 65 years old)
Mastoiditis
Erythromycin : Ear infection – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
mCNV - myopic choroidal neovascularisation
Aflibercept : Visual impairment due to myopic choroidal neovascularisation (myopic CNV) – only adults (18 years old or older)
Measurement of renal function
Desmopressin : Diagnostic test of the renal concentrating capacity – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 - 65 years old)
Mediastinal (thymic) large B-cell lymphoma
Axicabtagene ciloleucel : Primary mediastinal large B-cell lymphoma (PMBCL) – only adults (18 - 65 years old)
Lisocabtagene maraleucel : Primary mediastinal large B-cell lymphoma (PMBCL) – only adults (18 years old or older)
Medical termination of pregnancy
Mifepristone : Medical termination of developing intra-uterine pregnancy – women, only adults (18 - 65 years old)
Medullary thyroid carcinoma
Selpercatinib : RET-mutant medullary thyroid cancer – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Vandetanib : Medullary thyroid cancer (MTC) – only children (1 year - 12 years old) , adolescents (12 years - 18 years old)
Vandetanib : Medullary thyroid cancer (MTC) – only adults (18 years old or older)
Medulloblastoma
22-Oxovincaleukoblastine : Medulloblastoma – only children (1 year - 12 years old) , adolescents (12 years - 18 years old)
Megaloblastic anemia due to folate deficiency
Calcium folinate : Megaloblastic anaemia due to folate deficiency – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Folic acid : Folate-deficient megaloblastic anaemia – only children (1 year - 12 years old) , adolescents (12 years - 18 years old)
Folic acid : Folate-deficient megaloblastic anaemia – only adults (18 years old or older)
Megaloblastic anemia due to folate deficiency in pregnancy and lactation
Folic acid : Megaloblastic anemia due to folate deficiency in pregnancy and lactation – women, only adults (18 - 65 years old)
Megaloblastic anemia due to vitamin B>12< deficiency
Vitamin B12 : Addisonian pernicious anaemia, cobalamin deficiency, megaloblastic anemia due to vitamin B12 deficiency – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Ménière's disease
Betahistine : Ménière's syndrome – only adults (18 years old or older)
Cinnarizine : Vestibular disorders, Meniere's disease – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Cinnarizine : Vestibular disorders, Meniere's disease – only children (1 year - 12 years old)
Dimenhydrinate : Nausea, vertigo – only children (1 year - 12 years old) , adolescents (12 years - 18 years old)
Dimenhydrinate : Nausea, vertigo – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Meningeal leukemia
Cytarabine : Leukaemic meningitis – only adults (18 years old or older)
Methotrexate : Meningeal leukaemia – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Meningitis
Minocycline : Prophylaxis of meningitis – only adolescents (12 years - 18 years old)
Minocycline : Prophylaxis of meningitis – only adults (18 years old or older)
Menorrhagia
Norethisterone : Dysfunctional uterine bleeding, polymenorrhoea, menorrhagia, dysmenorrhoea, metropathia haemorrhagia – women, only adults (18 - 65 years old)
Merkel cell carcinoma
Retifanlimab : Metastatic or recurrent locally advanced Merkel cell carcinoma – only adults (18 years old or older)
Merkel cell tumour
Avelumab : Metastatic Merkel cell carcinoma (MCC) – only adults (18 years old or older)
Metabolic acidosis
Sodium bicarbonate : Metabolic acidosis – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Metachromatic leukodystrophy, juvenile type
Atidarsagene autotemcel : Metachromatic leukodystrophy with reduced arylsulfatase A enzymatic activity – only infants (40 days - 1 year old) , children (1 year - 12 years old)
Metachromatic leukodystrophy, late infantile type
Atidarsagene autotemcel : Metachromatic leukodystrophy with reduced arylsulfatase A enzymatic activity – only infants (40 days - 1 year old) , children (1 year - 12 years old)
Metastasis from malignant tumor of breast
Cyclophosphamide : Metastatic breast carcinoma – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Metastatic cholangiocarcinoma
Ivosidenib : Locally advanced or metastatic cholangiocarcinoma with an isocitrate dehydrogenase-1 R132 mutation – only adults (18 years old or older)
Metastatic malignant melanoma
Lomustine : Malignant melanoma (metastatic) – only adults (18 years old or older)
Pembrolizumab : Advanced (unresectable or metastatic) melanoma – only adults (18 - 65 years old)
Metastatic renal cell carcinoma
Aldesleukin : Metastatic renal cell carcinoma (metastatic RCC) – only adults (18 years old or older)
Methotrexate poisoning
Calcium folinate : Calcium folinate rescue in methotrexate therapy – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Glucarpidase : Reduction of toxic plasma methotrexate concentration – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Metropathia hemorrhagica
Norethisterone : Dysfunctional uterine bleeding, polymenorrhoea, menorrhagia, dysmenorrhoea, metropathia haemorrhagia – women, only adults (18 - 65 years old)
Microalbuminuric diabetic nephropathy
Ramipril : Renal disease in patients with diabetes and microalbuminuria – only adults (18 years old or older)
Microglioma
Thiotepa : Central nervous system lymphoma – only adults (18 years old or older)
Microscopic polyarteritis
Avacopan : Granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) – only adults (18 years old or older)
Rituximab : Granulomatosis with polyangiitis, microscopic polyangiitis – only adults (18 years old or older)
Middle insomnia
Doxepin : Insomnia – only adults (18 years old or older)
Migraine
Almotriptan : Migraine attacks – only adults (18 years old or older)
Atogepant : Migraine – only adults (18 years old or older)
Diclofenac : Migraine – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Dihydroergotamine : Migraine – only adults (18 - 65 years old)
Eptinezumab : Prophylaxis of migraine – only adults (18 years old or older)
Erenumab : Prophylaxis of migraine – only elderly (65 years old or older)
Flunarizine : Prophylaxis of migraine – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Flurbiprofen : Rheumatoid disease, osteoarthritis, ankylosing spondylitis, musculoskeletal disorders, periarthritis, frozen shoulder, bursitis – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Frovatriptan : Migraine – only adults (18 years old or older)
Galcanezumab : Migraine
Mefenamic acid : Migraine – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Paracetamol : Pain, fever – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Propranolol : Migraine – only children (1 year - 12 years old)
Propranolol : Migraine – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Rimegepant : Episodic migraine – only adults (18 years old or older)
Sumatriptan : Migraine attacks – only adolescents (12 years - 18 years old) , adults (18 - 65 years old)
Tolfenamic acid : Acute migraine – only adults (18 years old or older)
Zolmitriptan : Treatment of migraine headache with or without aura – only adults (18 - 65 years old)
Migraine with aura
Acetylsalicylic acid : Migraine with or without aura – only adults (18 years old or older)
Eletriptan : Headache phase of migraine attacks with or without aura – only adults (18 - 65 years old)
Rimegepant : Migraine with or without aura – only adults (18 years old or older)
Rizatriptan : Headache phase of migraine attacks with or without aura – only adults (18 years old or older)
Migraine without aura
Acetylsalicylic acid : Migraine with or without aura – only adults (18 years old or older)
Eletriptan : Headache phase of migraine attacks with or without aura – only adults (18 - 65 years old)
Rimegepant : Migraine with or without aura – only adults (18 years old or older)
Rizatriptan : Headache phase of migraine attacks with or without aura – only adults (18 years old or older)
Mild hemophilia A
Desmopressin : Mild to moderate haemophilia, von Willebrand's disease – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 - 65 years old)
Mild pain
Ibuprofen : Mild to moderate pain – only adolescents (12 years - 18 years old) , adults (18 - 65 years old)
Ibuprofen : Mild to moderate pain – only infants (40 days - 1 year old) , children (1 year - 12 years old)
Mild persistent asthma
Mometasone : Mild to moderate persistent asthma – only adults (18 years old or older)
Montelukast : Mild to moderate persistent asthma – only children (1 year - 12 years old) , adolescents (12 years - 18 years old)
Montelukast : Mild to moderate persistent asthma – only adults (18 years old or older)
Minimal change disease
Prednisolone : Minimal change glomerulonephritis – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Missed abortion
Oxytocin : Incomplete abortion, inevitable abortion, missed abortion – women, only adults (18 - 65 years old)
Mixed anxiety and depressive disorder
Alprazolam : Moderate or severe anxiety, anxiety associated with depression – only elderly (65 years old or older)
Alprazolam : Moderate or severe anxiety, anxiety associated with depression – only adults (18 - 65 years old)
Buspirone : Anxiety disorders – only adults (18 years old or older)
Mixed collagen vascular disease
Prednisolone : Mixed collagen vascular disease – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Mixed hyperlipidaemia
Atorvastatin : Primary hypercholesterolaemia, combined hyperlipidaemia – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Bezafibrate : Severe hypertriglyceridaemia, mixed hyperlipidaemia – only adults (18 years old or older)
Ciprofibrate : Severe hypertriglyceridaemia, mixed hyperlipidaemia – only adults (18 years old or older)
Fenofibrate : Severe hypertriglyceridaemia, mixed hyperlipidaemia – only adults (18 years old or older)
Gemfibrozil : Severe hypertriglyceridaemia, mixed hyperlipidaemia, primary hypercholesterolaemia – only adults (18 years old or older)
Inclisiran : Mixed dyslipidaemia – only adults (18 years old or older)
MMN - Motor neuropathy with multiple conduction block
Immunoglobulins, normal human, IV : Multifocal motor neuropathy (MMN) – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Moderate haemophilia B with inhibitor
Desmopressin : Mild to moderate haemophilia, von Willebrand's disease – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 - 65 years old)
Moderate haemophilia B without inhibitor
Desmopressin : Mild to moderate haemophilia, von Willebrand's disease – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 - 65 years old)
Etranacogene dezaparvovec : Severe and moderately severe Haemophilia B without Factor IX inhibitors – only adults (18 years old or older)
Moderate hemophilia A
Desmopressin : Mild to moderate haemophilia, von Willebrand's disease – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 - 65 years old)
Moderate major depression
Fluoxetine : Moderate to severe major depressive episode – only children (1 year - 12 years old) , adolescents (12 years - 18 years old)
Moderate manic bipolar I disorder
Asenapine : Moderate to severe manic episodes associated with bipolar I disorder – only adults (18 years old or older)
Haloperidol : Moderate to severe manic episodes associated with bipolar I disorder – only elderly (65 years old or older)
Haloperidol : Moderate to severe manic episodes associated with bipolar I disorder – only adults (18 - 65 years old)
Quetiapine : Schizophrenia, moderate to severe manic episodes in bipolar disorder – only adults (18 years old or older)
Risperidone : Moderate to severe manic episodes associated with bipolar disorders – only adults (18 - 65 years old)
Risperidone : Moderate to severe manic episodes associated with bipolar disorders – only elderly (65 years old or older)
Ziprasidone : Manic or mixed episodes of moderate severity in bipolar disorder – only adults (18 years old or older)
Moderate pain
Ibuprofen : Mild to moderate pain – only adolescents (12 years - 18 years old) , adults (18 - 65 years old)
Ibuprofen : Mild to moderate pain – only infants (40 days - 1 year old) , children (1 year - 12 years old)
Nalbuphine : Moderate to severe pain, postoperative pain – only children (1 year - 12 years old) , adolescents (12 years - 18 years old)
Nalbuphine : Moderate to severe pain, postoperative pain – only adults (18 years old or older)
Pethidine : Moderate to severe pain – only children (1 year - 12 years old) , adolescents (12 years - 18 years old)
Pethidine : Moderate to severe pain – only elderly (65 years old or older)
Pethidine : Moderate to severe pain – only adults (18 - 65 years old)
Tapentadol : Moderate to severe acute pain – only adults (18 years old or older)
Tramadol : Moderate to severe pain – only children (1 year - 12 years old)
Tramadol : Moderate to severe pain – only adults (18 years old or older)
Moderate persistent asthma
Mometasone : Mild to moderate persistent asthma – only adults (18 years old or older)
Montelukast : Mild to moderate persistent asthma – only children (1 year - 12 years old) , adolescents (12 years - 18 years old)
Montelukast : Mild to moderate persistent asthma – only adults (18 years old or older)
Moderate pulmonary hypertension
Iloprost : Primary pulmonary hypertension, classified as NYHA functional class III – only adults (18 years old or older)
Molybdenum cofactor deficiency complementation group A
Fosdenopterin : Molybdenum cofactor deficiency (MoCD) Type A – only minors (0 - 18 years old) , adults (18 - 65 years old)
Monkeypox
Tecovirimat : Smallpox, monkeypox, cowpox – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Mood disorder
Lithium : Prophylactic treatment of recurrent affective disorders – only adults (18 years old or older)
Motion sickness
Cinnarizine : Motion sickness – only children (1 year - 12 years old)
Cinnarizine : Motion sickness – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Dimenhydrinate : Nausea, vertigo – only children (1 year - 12 years old) , adolescents (12 years - 18 years old)
Dimenhydrinate : Nausea, vertigo – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Diphenhydramine : Motion sickness – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Diphenhydramine : Motion sickness – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Meclozine : Motion sickness – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Movement disorder
Tetrabenazine : Organic central nervous system movement disorders – only adults (18 - 65 years old)
MRI of brain
Gadobutrol : Cranial and spinal magnetic resonance imaging (MRI) – only minors (0 - 18 years old) , adults (18 years old or older)
Gadopiclenol : Magnetic resonance imaging – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Gadoteric acid : Magnetic resonance imaging (MRI) of brain – only minors (0 - 18 years old) , adults (18 years old or older)
MRI of breast
Gadopiclenol : Magnetic resonance imaging – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
MRI of head and spine with contrast
Gadoversetamide : Magnetic resonance imaging (MRI) of the central nervous system (CNS) and liver – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
MRI of kidneys
Gadopiclenol : Magnetic resonance imaging – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
MRI of lungs
Gadopiclenol : Magnetic resonance imaging – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
MRI of pancreas
Gadopiclenol : Magnetic resonance imaging – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
MRI of spine
Gadobutrol : Cranial and spinal magnetic resonance imaging (MRI) – only minors (0 - 18 years old) , adults (18 years old or older)
Gadopiclenol : Magnetic resonance imaging – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Gadoteric acid : Magnetic resonance imaging (MRI) of spine – only minors (0 - 18 years old) , adults (18 years old or older)
Gadoversetamide : Magnetic resonance imaging (MRI) of the central nervous system (CNS) and liver – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Mucocutaneous candidiasis
Fluconazole : Mucosal candidiasis – only newborns (0 - 40 days old)
Fluconazole : Mucosal candidiasis – only infants (40 days - 1 year old) , children (1 year - 12 years old)
Mucolytic drug therapy
Acetylcysteine : Liquefaction of secretions in bronchitis, emphysema, tracheobronchitis, chronic asthmatic bronchitis – only infants (40 days - 1 year old)
Acetylcysteine : Liquefaction of secretions in bronchitis, emphysema, tracheobronchitis, chronic asthmatic bronchitis – only children (1 year - 12 years old)
Acetylcysteine : Liquefaction of secretions in bronchitis, emphysema, tracheobronchitis, chronic asthmatic bronchitis – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Ambroxol : Mucolytic therapy – only children (1 year - 12 years old)
Ambroxol : Mucolytic therapy – only adolescents (12 years - 18 years old) , adults (18 - 65 years old)
Mucopolysaccharidosis, MPS-I
Laronidase : Mucopolysaccharidosis I – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 - 65 years old)
Mucopolysaccharidosis, MPS-II
Idursulfase : Mucopolysaccharidosis type II – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Mucopolysaccharidosis, MPS-VII
Vestronidase alfa : Mucopolysaccharidosis VII – only adults (18 years old or older)
Mucormycosis
Amphotericin B : Mucormycosis – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Isavuconazole : Invasive aspergillosis, mucormycosis – only adults (18 years old or older)
Multibacillary leprosy
Dapsone : Multibacillary leprosy – only children (1 year - 12 years old)
Dapsone : Multibacillary leprosy – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Multidrug resistant tuberculosis
4-Aminosalicylic acid : Multi-drug resistant tuberculosis – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old)
4-Aminosalicylic acid : Multi-drug resistant tuberculosis – only adults (18 years old or older)
Bedaquiline : Multidrug-resistant tuberculosis (MDR-TB) – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Delamanid : Multi-drug resistant tuberculosis (MDR-TB) – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old)
Delamanid : Multi-drug resistant tuberculosis (MDR-TB) – only adults (18 - 65 years old)
Multiple myeloma (clinical)
22-Oxovincaleukoblastine : Multiple myeloma – only adults (18 years old or older)
Belantamab mafodotin : Multiple myeloma – only adults (18 years old or older)
Bendamustine : Multiple myeloma – only adults (18 years old or older)
Bortezomib : Multiple myeloma – only adults (18 - 65 years old)
Carfilzomib : Multiple myeloma – only adults (18 years old or older)
Ciltacabtagene autoleucel : Multiple myeloma – only adults (18 years old or older)
Cyclophosphamide : Multiple Myeloma – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Daratumumab : Multiple myeloma – only adults (18 - 65 years old)
Dexamethasone : Multiple myeloma – only elderly (65 years old or older)
Dexamethasone : Multiple myeloma – only adults (18 - 65 years old)
Doxorubicin : Multiple myeloma – only adults (18 years old or older)
Elotuzumab : Multiple myeloma – only adults (18 - 65 years old)
Elranatamab : Relapsed and refractory multiple myeloma – only adults (18 years old or older)
Idecabtagene vicleucel : Relapsed and refractory multiple myeloma – only adults (18 years old or older)
Interferon, alfa-2b : Multiple myeloma – only adults (18 - 65 years old)
Isatuximab : Multiple myeloma – only adults (18 years old or older)
Ixazomib : Multiple myeloma – only adults (18 years old or older)
Lenalidomide : Multiple myeloma – only adults (18 - 65 years old)
Melphalan : Multiple myeloma – only adults (18 years old or older)
Panobinostat : Multiple myeloma – only adults (18 - 65 years old)
Pomalidomide : Multiple myeloma – only adults (18 years old or older)
Prednisolone : Multiple myeloma – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Talquetamab : Relapsed and refractory multiple myeloma – only adults (18 years old or older)
Teclistamab : Multiple myeloma – only adults (18 - 65 years old)
Thalidomide : Multiple myeloma – only adults (18 years old or older)
Thiotepa : Multiple myeloma – only adults (18 years old or older)
Multiple sclerosis
Daclizumab : Relapsing multiple sclerosis (RMS) – only adults (18 years old or older)
Interferon beta-1b : Multiple sclerosis – only adolescents (12 years - 18 years old) , adults (18 - 65 years old)
Mitoxantrone : Multiple sclerosis – only adults (18 years old or older)
Ocrelizumab : Multiple sclerosis (RMS) – only adults (18 years old or older)
Multiple system atrophy
Prednisolone : Shy-Drager syndrome – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Muscle spasticity
Diazepam : Upper motor neuronic spasticity – only children (1 year - 12 years old) , adolescents (12 years - 18 years old)
Diazepam : Upper motor neuronic spasticity – only elderly (65 years old or older)
Diazepam : Upper motor neuronic spasticity – only adults (18 - 65 years old)
Tizanidine : Spasticity – only adults (18 years old or older)
Musculoskeletal pain
Dexibuprofen : Mild to moderate pain – only adults (18 years old or older)
Dexketoprofen : Pain – only adults (18 years old or older)
Naproxen : Musculoskeletal disorders – only adults (18 years old or older)
Orphenadrine : Musculoskeletal pain – only adults (18 years old or older)
Myalgia
Ibuprofen : Muscular pain, sprains, strains, sports injuries – only adolescents (12 years - 18 years old) , adults (18 - 65 years old)
Paracetamol : Pain, fever – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Myasthenia gravis
Ambenonium : Myasthenia gravis – only adults (18 years old or older)
Neostigmine : Myasthenia Gravis – only minors (0 - 18 years old) , adults (18 years old or older)
Pyridostigmine : Myasthenia gravis – only children (1 year - 12 years old)
Pyridostigmine : Myasthenia gravis – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Zilucoplan : Myasthenia gravis in patients who are anti-acetylcholine receptor antibody positive – only adults (18 years old or older)
Mycobacterium tuberculosis
4-Aminosalicylic acid : Multi-drug resistant tuberculosis – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old)
4-Aminosalicylic acid : Multi-drug resistant tuberculosis – only adults (18 years old or older)
Mycosis
Amphotericin B : Severe systemic and/or deep mycoses – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Mycosis fungoides (clinical)
Chlormethine : Mycosis fungoides-type cutaneous T-cell lymphoma (MF-type CTCL) – only adults (18 years old or older)
Methotrexate : Mycosis fungoides – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Mogamulizumab : Mycosis fungoides (MF) – only adults (18 - 65 years old)
Myelodysplastic syndrome (clinical)
Azacitidine : Myelodysplastic syndromes, chronic myelomonocytic leukaemia, acute myeloid leukaemia – only adults (18 years old or older)
Lenalidomide : Myelodysplastic syndromes – only adults (18 - 65 years old)
Myelodysplastic syndrome with ring sideroblasts and single lineage dysplasia
Luspatercept : Anaemia due to myelodysplastic syndromes (MDS) – only adults (18 years old or older)
Myelofibrosis
Busulfan : Myelofibrosis – only adults (18 - 65 years old)
Ruxolitinib : Myelofibrosis (MF) – only adults (18 years old or older)
Myeloid neoplasm associated with beta-type platelet-derived growth factor receptor gene rearrangement
Imatinib : Myelodysplastic/myeloproliferative diseases (MDS/MPD) with platelet-derived growth factor receptor (PDGFR) gene re-arrangements – only adults (18 years old or older)
Myeloid/lymphoid neoplasm associated with PDGFRA rearrangement
Imatinib : Advanced hypereosinophilic syndrome (HES) and/or chronic eosinophilic leukaemia (CEL) with FIP1L1-PDGFRa rearrangement – only adults (18 years old or older)
Myelosclerosis with myeloid metaplasia
Fedratinib : Primary myelofibrosis, post polycythaemia vera myelofibrosis, post essential thrombocythaemia myelofibrosis – only adults (18 years old or older)
Myocardial infarction
Atenolol : Myocardial infarction – only adults (18 years old or older)
Captopril : Myocardial infarction – only adults (18 years old or older)
Clopidogrel : Myocardial infarction – only adults (18 years old or older)
Docosahexaenoic acid : Secondary prevention after secondary myocardial infarction – only adults (18 years old or older)
Eicosapentaenoic acid : Secondary prevention after secondary myocardial infarction – only adults (18 years old or older)
Myocardial ischemia
Glyceryl trinitrate : Myocardial ischemia – only adults (18 years old or older)
Myotonia
Mexiletine : Myotonia in non-dystrophic myotonic disorders – only adults (18 years old or older)

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