Indications A-Z

RxReasoner presents a comprehensive list of pharmaceutical treatment indications drawn from medicine package inserts issued by authoritative regulatory bodies globally.

This index serves as a valuable tool to quickly access information on the recommended therapeutic approaches for different medical conditions, diseases or symptoms.

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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Indications starting with 'S'

Indication	Treatments
Salt-losing congenital adrenal hyperplasia	Fludrocortisone : Salt-losing adrenogenital syndrome – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Sarcoidosis	Prednisolone : Sarcoidosis – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Sarcoma of soft tissue	22-Oxovincaleukoblastine : Soft tissue sarcoma – only adults (18 years old or older) Dacarbazine : Soft tissue sarcoma – only adults (18 - 65 years old) Melphalan : Soft tissue sarcoma – only adults (18 years old or older) Olaratumab : Soft tissue sarcoma – only adults (18 years old or older) Pazopanib : Soft-tissue sarcoma (STS) – only adults (18 years old or older) Trabectedin : Soft tissue sarcoma – only adults (18 years old or older)
Saturnine poisoning	Calcium gluconate : Fluoride poisoning, lead poisoning – only adults (18 years old or older)
Scabies	Ivermectin : Human sarcoptic scabies – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Permethrin : Scabies – only infants (40 days - 1 year old) , children (1 year - 12 years old) Permethrin : Scabies, crab lice – only adolescents (12 years - 18 years old) , adults (18 years old or older) Phenothrin : Scabies, crab lice – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Scald of skin	Chlorhexidine : Burns, scalds, scratches, cuts, abrasions, sunburn blisters, infected cracked skin – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Scalp psoriasis	Calcipotriol : Psoriasis vulgaris – only adults (18 years old or older) Clobetasol propionate : Scalp psoriasis – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Scanty tear production	Acetylcysteine : Deficient tear secretion – only adults (18 - 65 years old)
Schizoaffective disorder	Haloperidol : Schizoaffective disorder – only elderly (65 years old or older) Haloperidol : Schizoaffective disorder – only adults (18 - 65 years old) Paliperidone : Schizoaffective disorder – only adults (18 - 65 years old)
Schizophrenia	Aripiprazole : Schizophrenia – only adolescents (12 years - 18 years old) Aripiprazole : Schizophrenia – only adults (18 years old or older) Brexpiprazole : Schizophrenia – only adults (18 - 65 years old) Chlorpromazine : Schizophrenia, autism – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) Chlorpromazine : Schizophrenia, mania, hypomania – only elderly (65 years old or older) Chlorpromazine : Schizophrenia, mania, hypomania – only adults (18 - 65 years old) Clozapine : Treatment-resistant schizophrenia – only adults (18 years old or older) Haloperidol : Schizophrenia – only adolescents (12 years - 18 years old) Haloperidol : Schizophrenia – only elderly (65 years old or older) Haloperidol : Schizophrenia – only adults (18 - 65 years old) Levomepromazine : Schizophrenia – only adults (18 - 65 years old) Levosulpiride : Acute schizophrenia – only adults (18 years old or older) Lurasidone : Schizophrenia – only adolescents (12 years - 18 years old) Lurasidone : Schizophrenia – only adults (18 years old or older) Olanzapine : Schizophrenia – only elderly (65 years old or older) Olanzapine : Schizophrenia – only adults (18 - 65 years old) Paliperidone : Schizophrenia – only adolescents (12 years - 18 years old) , adults (18 years old or older) Perphenazine : Schizophrenia – only adults (18 - 65 years old) Quetiapine : Schizophrenia, moderate to severe manic episodes in bipolar disorder – only adults (18 years old or older) Risperidone : Schizophrenia – only adults (18 - 65 years old) Risperidone : Schizophrenia – only elderly (65 years old or older) Ziprasidone : Schizophrenia – only adults (18 years old or older) Zuclopenthixol : Schizophrenia, psychoses – only adults (18 years old or older)
Scleritis	Dexamethasone : Scleritis – only adults (18 years old or older) Prednisolone : Scleritis – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Scratch marks	Chlorhexidine : Burns, scalds, scratches, cuts, abrasions, sunburn blisters, infected cracked skin – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Seborrheic dermatitis	Betamethasone : Seborrhoeic dermatitis – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Ciclopirox olamine : Seborrhoeic dermatitis – only adolescents (12 years - 18 years old) , adults (18 years old or older) Clobetasone : Atopic dermatitis, irritant or allergic contact dermatitis, seborrhoeic dermatitis, nappy rash, photodermatitis – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Fluocinonide : Seborrheic dermatitis – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Ketoconazole : Seborrheic dermatitis – only adolescents (12 years - 18 years old) , adults (18 years old or older) Methylprednisolone : Seborrheic dermatitis – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Secondary amenorrhea	Medroxyprogesterone : Secondary amenorrhoea – women, only adults (18 - 65 years old)
Secondary angle-closure glaucoma	Acetazolamide : Secondary or acute narrow angle glaucoma – only adults (18 years old or older)
Secondary gout	Lesinurad : Hyperuricaemia in gout – only adults (18 years old or older)
Secondary hypocortisolism	Dexamethasone : Secondary adrenocortical insufficiency – only adults (18 years old or older) Fludrocortisone : Secondary adrenocortical insufficiency – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Methylprednisolone : Secondary adrenocortical insufficiency – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Secondary immune deficiency disorder	Human normal immunoglobulin G : Primary immunodeficiency syndromes with impaired antibody production, secondary immunodeficiencies (SID) – only minors (0 - 18 years old) , adults (18 - 65 years old) Immunoglobulins, normal human, IV : Secondary immunodeficiencies – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Secondary malignant neoplasm of brain	Carmustine : Glioblastoma, brain-stem gliomas, medulloblastoma, astrocytoma, ependymoma, brain metastases – only adults (18 years old or older)
Secondary open-angle glaucoma	Carteolol : Ocular hypertension, chronic open angle glaucoma, secondary glaucomas – only adults (18 years old or older)
Secondary progressive multiple sclerosis	Siponimod : Secondary progressive multiple sclerosis (SPMS)
Secondary syphilis	Doxycycline : Primary and secondary syphilis – only adults (18 years old or older)
Sedation	Alfentanil : Analgesia, suppression of respiratory activity – only adults (18 - 65 years old) Midazolam : Sedation during minor medical procedures – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) Midazolam : Sedation during minor medical procedures – only elderly (65 years old or older) Midazolam : Sedation during minor medical procedures – only adults (18 - 65 years old) Midazolam : Sedation in intensive care – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Promethazine : Sedation – only adults (18 - 65 years old) Remimazolam : Procedural sedation – only adults (18 years old or older)
Seizure	Midazolam : Prolonged, acute, convulsive seizures – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old)
Seizure disorder	Clonazepam : Seizure – only newborns (0 - 40 days old) , infants (40 days - 1 year old) Clonazepam : Seizure – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) Clonazepam : Seizure – only elderly (65 years old or older) Clonazepam : Seizure – only adults (18 - 65 years old)
Senile atrophic vaginitis	Estradiol : Atrophic vaginitis in menopause – only adults (18 - 65 years old) Estriol : Atrophic vaginitis – women, only adults (18 years old or older) Ospemifene : Moderate to severe symptomatic vulvar and vaginal atrophy (VVA) in post-menopausal women – women, only adults (18 years old or older) Prasterone : Vulvar and vaginal atrophy in postmenopausal women having moderate to severe symptoms – women, only adults (18 years old or older)
Senile cardiac amyloidosis	Tafamidis : Transthyretin amyloidosis – only adults (18 - 65 years old)
Senile degeneration of brain	Meclofenoxate : Cerebral aging – only adults (18 years old or older)
Senile hyperkeratosis	Fluorouracil : Pre-malignant and malignant skin lesions – only adults (18 years old or older)
Sensation of irritation of eye proper	Naphazoline : Eye irritation – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Septic shock	Dobutamine : Cardiac decompensation, disturbed ventricular function – only minors (0 - 18 years old) Dobutamine : Cardiac decompensation, disturbed ventricular function – only adults (18 years old or older)
Sequelae of injuries of head	Meclofenoxate : Neurological or psychological sequelea of head injury – only adults (18 years old or older)
Serum sickness caused by drug	Dexchlorpheniramine : Perennial and seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis, urticaria, angioedema Hydrocortisone : Serum sickness – only minors (0 - 18 years old) , adults (18 years old or older) Methylprednisolone : Serum sickness caused by drug – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Prednisolone : Serum sickness caused by drug – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Severe anxiety (panic)	Lorazepam : Severe anxiety – only elderly (65 years old or older) Lorazepam : Severe anxiety – only adults (18 - 65 years old)
Severe asthma	Dupilumab : Severe asthma with type 2 inflammation – only adolescents (12 years - 18 years old) , adults (18 years old or older) Tezepelumab : Severe asthma inadequately controlled – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Severe bipolar I disorder, single manic episode with psychotic features	Quetiapine : Schizophrenia, moderate to severe manic episodes in bipolar disorder – only adults (18 years old or older)
Severe bipolar I disorder, single manic episode without psychotic features	Quetiapine : Schizophrenia, moderate to severe manic episodes in bipolar disorder – only adults (18 years old or older)
Severe chronic obstructive pulmonary disease	Roflumilast : Severe chronic obstructive pulmonary disease (COPD) associated with chronic bronchitis – only adults (18 years old or older)
Severe deficiency of arylsulfatase	Atidarsagene autotemcel : Metachromatic leukodystrophy with reduced arylsulfatase A enzymatic activity – only infants (40 days - 1 year old) , children (1 year - 12 years old)
Severe haemophilia B without inhibitor	Etranacogene dezaparvovec : Severe and moderately severe Haemophilia B without Factor IX inhibitors – only adults (18 years old or older)
Severe hemophilia A	Emicizumab : Haemophilia A with factor VIII inhibitors, severe haemophilia A – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Severe major depression	Fluoxetine : Moderate to severe major depressive episode – only children (1 year - 12 years old) , adolescents (12 years - 18 years old)
Severe manic bipolar I disorder with psychotic features	Asenapine : Moderate to severe manic episodes associated with bipolar I disorder – only adults (18 years old or older)
Severe manic bipolar I disorder without psychotic features	Asenapine : Moderate to severe manic episodes associated with bipolar I disorder – only adults (18 years old or older)
Severe myoclonic epilepsy in infancy	Cannabidiol : Seizures associated with Lennox-Gastaut syndrome or Dravet syndrome – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Stiripentol : Severe myoclonic epilepsy in infancy (SMEI, Dravet's syndrome) – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old)
Severe pain	Buprenorphine : Severe pain – only adults (18 years old or older) Ethanol : Severe and chronic pain – only adults (18 years old or older) Morphine : Severe pain – only children (1 year - 12 years old) Morphine : Severe pain – only adolescents (12 years - 18 years old) , adults (18 years old or older) Nalbuphine : Moderate to severe pain, postoperative pain – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) Nalbuphine : Moderate to severe pain, postoperative pain – only adults (18 years old or older) Oxycodone : Severe pain which requires long-term opioid treatment – only adolescents (12 years - 18 years old) , adults (18 years old or older) Pethidine : Moderate to severe pain – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) Pethidine : Moderate to severe pain – only elderly (65 years old or older) Pethidine : Moderate to severe pain – only adults (18 - 65 years old) Tapentadol : Moderate to severe acute pain – only adults (18 years old or older) Tramadol : Moderate to severe pain – only children (1 year - 12 years old) Tramadol : Moderate to severe pain – only adults (18 years old or older)
Severe persistent asthma	Mometasone : Severe persistent asthma – only adults (18 years old or older)
Severe pre-eclampsia	Nicardipine : Severe pre-eclampsia – women, only adults (18 - 65 years old)
Severe pulmonary hypertension	Iloprost : Primary pulmonary hypertension, classified as NYHA functional class III – only adults (18 years old or older)
Sézary's disease	Mogamulizumab : Sézary syndrome (SS) – only adults (18 - 65 years old)
Shock	Betamethasone : Severe shock – only children (1 year - 12 years old) Betamethasone : Severe shock – only adolescents (12 years - 18 years old) , adults (18 years old or older) Dexamethasone : Shock – only adults (18 years old or older) Hydrocortisone : Shock – only newborns (0 - 40 days old) , infants (40 days - 1 year old) , children (1 year - 12 years old) Hydrocortisone : Shock – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Short bowel syndrome	Cimetidine : Short bowel syndrome – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) Cimetidine : Short bowel syndrome – only infants (40 days - 1 year old) Cimetidine : Short bowel syndrome – only adults (18 years old or older) Teduglutide : Short Bowel Syndrome (SBS) – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Shoulder pain	Oxaprozin : Shoulder pain
Sickle cell anemia	Thiotepa : Sickle cell anaemia – only children (1 year - 12 years old) , adolescents (12 years - 18 years old)
Sickling disorder due to hemoglobin S	Exagamglogene autotemcel : Sickle cell disease – only adolescents (12 years - 18 years old) , adults (18 years old or older) Voxelotor : Haemolytic anaemia due to sickle cell disease (SCD) – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Simple pulmonary alveolitis	Prednisolone : Pulmonary alveolitis – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Single manic episode, moderate	Olanzapine : Moderate to severe manic episode – only elderly (65 years old or older) Olanzapine : Moderate to severe manic episode – only adults (18 - 65 years old)
Single manic episode, severe, with psychosis	Olanzapine : Moderate to severe manic episode – only elderly (65 years old or older) Olanzapine : Moderate to severe manic episode – only adults (18 - 65 years old)
Singultus	Chlorpromazine : Intractable hiccup – only elderly (65 years old or older) Chlorpromazine : Intractable hiccup – only adults (18 - 65 years old)
Sinus tachycardia	Landiolol : Sinus tachycardia – only adults (18 - 65 years old)
Sinusitis	Serrapeptase : Sinusitis – only adults (18 years old or older)
Skin fissure	Dexpanthenol : Superficial skin lesion, skin inflammation
SLE glomerulonephritis syndrome	Cyclophosphamide : Severe progressive forms of lupus nephritis – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Prednisolone : Lupus nephritis – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
SLE glomerulonephritis syndrome, WHO class III	Voclosporin : Class III, IV or V lupus nephritis – only adults (18 years old or older)
SLE glomerulonephritis syndrome, WHO class IV	Voclosporin : Class III, IV or V lupus nephritis – only adults (18 years old or older)
SLE glomerulonephritis syndrome, WHO class V	Voclosporin : Class III, IV or V lupus nephritis – only adults (18 years old or older)
Sleep-wake schedule disorder due to jet lag	Promethazine : Temporary disturbances of sleep pattern – only adults (18 years old or older)
Sleeplessness	Daridorexant : Insomnia – only adults (18 years old or older) Flunitrazepam : Insomnia – only elderly (65 years old or older) Flunitrazepam : Insomnia – only adults (18 - 65 years old) Triazolam : Insomnia – only adults (18 years old or older) Zolpidem : Insomnia – only elderly (65 years old or older) Zolpidem : Insomnia – only adults (18 - 65 years old) Zopiclone : Insomnia – only adults (18 years old or older)
Small bowel fistula	Lanreotide : Postoperative pancreatic fistula, postoperative small bowel fistula – only adults (18 years old or older)
Small cell carcinoma of lung	22-Oxovincaleukoblastine : Small cell bronchogenic carcinoma – only adults (18 years old or older) Atezolizumab : Small cell carcinoma of lung – only adults (18 years old or older) Carboplatin : Small cell carcinoma of the lung – only adults (18 years old or older) Cis-Diaminedichloroplatinum : Small cell carcinoma of lung – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Cyclophosphamide : Small cell lung cancer – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Epirubicin : Small cell lung cancer – only adults (18 years old or older) Etoposide : Small cell lung cancer (SCLC) – only adults (18 years old or older)
Smallpox	Smallpox, live attenuated : Active immunisation against smallpox – only adults (18 years old or older) Tecovirimat : Smallpox, monkeypox, cowpox – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Smoking cessation drug therapy	Bupropion : Smoking cessation in nicotine-dependent patients – only adults (18 years old or older) Nicotine : Tobacco dependence, nicotine withdrawal symptoms, smoking cessation – only adults (18 years old or older) Varenicline : Smoking cessation – only adults (18 years old or older)
Smoking cessation therapy	Nicotine : Tobacco dependence, nicotine withdrawal symptoms, smoking cessation – only adults (18 years old or older)
Social phobia	Escitalopram : Social anxiety disorder – only adults (18 - 65 years old) Moclobemide : Social phobia – only adults (18 years old or older) Paroxetine : Social anxiety disorders (social phobia) – only adults (18 years old or older) Sertraline : Social anxiety disorder – only adults (18 years old or older) Venlafaxine : Social Anxiety Disorder (Social Phobia) – only adults (18 years old or older)
Solar degeneration	Hydroxychloroquine : Rheumatoid arthritis, discoid and systemic lupus erythematosus, sunlight damaged skin – only adults (18 years old or older)
Solar erythema	Chlorhexidine : Burns, scalds, scratches, cuts, abrasions, sunburn blisters, infected cracked skin – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Solar keratosis	Diclofenac : Actinic keratosis – only adults (18 years old or older) Fluorouracil : Pre-malignant and malignant skin lesions – only adults (18 years old or older) Imiquimod : Actinic keratosis – only adults (18 years old or older)
Solid tumour with neurotrophic receptor tyrosine kinase	Larotrectinib : Solid tumours that display a Neurotrophic Tyrosine Receptor Kinase (NTRK) gene fusion – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) Larotrectinib : Solid tumours that display a Neurotrophic Tyrosine Receptor Kinase (NTRK) gene fusion – only adults (18 - 65 years old)
Somatoform disorder	Levosulpiride : Somatoform disorders – only adults (18 years old or older)
Sore mouth	Dichlorobenzyl alcohol : Sore mouth – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Spasm	Chlordiazepoxide : Muscle spasm – only elderly (65 years old or older) Chlordiazepoxide : Muscle spasm – only adults (18 - 65 years old) Diazepam : Muscle spasm – only elderly (65 years old or older) Diazepam : Muscle spasm – only adults (18 - 65 years old)
Spasm of back muscles	Thiocolchicoside : Painful muscle spasms in acute spinal pathology – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Spasm of bladder	Butylscopolamine : Spasm, endoscopy of the genito-urinary tract or gastro- intestinal tract, Irritable Bowel Syndrome – only children (1 year - 12 years old) Butylscopolamine : Spasm, endoscopy of the genito-urinary tract or gastro- intestinal tract, Irritable Bowel Syndrome – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Spasm of cervix uteri	Butylscopolamine : Spasm, endoscopy of the genito-urinary tract or gastro- intestinal tract, Irritable Bowel Syndrome – only children (1 year - 12 years old) Butylscopolamine : Spasm, endoscopy of the genito-urinary tract or gastro- intestinal tract, Irritable Bowel Syndrome – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Spasmodic movement	Primidone : Grand mal and psychomotor (temporal lobe) epilepsy, focal or Jacksonian seizures, myoclonic jerks, akinetic attacks – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Spasmodic rhinorrhea	Azelastine : Seasonal allergic rhinitis – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Budesonide : Seasonal and perennial allergic rhinitis – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Cetirizine : Seasonal and perennial allergic rhinitis, chronic idiopathic urticaria – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Dexchlorpheniramine : Perennial and seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis, urticaria, angioedema Fexofenadine : Seasonal allergic rhinitis – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Methylprednisolone : Seasonal allergic rhinitis – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) Methylprednisolone : Seasonal allergic rhinitis – only adults (18 years old or older) Mizolastine : Seasonal allergic rhinoconjunctivitis (hay fever), perennial allergic rhinoconjunctivitis, urticaria – only adolescents (12 years - 18 years old) , adults (18 years old or older) Mometasone : Seasonal allergic rhinitis – only children (1 year - 12 years old) Mometasone : Seasonal allergic rhinitis – only adolescents (12 years - 18 years old) , adults (18 years old or older) Triamcinolone : Seasonal allergic rhinitis – only adults (18 years old or older)
Spasmodic torticollis	Botulinum toxin type A : Idiopathic cervical dystonia (spasmodic torticollis) – only adults (18 years old or older) Botulinum toxin type B : Cervical dystonia (torticollis) – only adults (18 years old or older)
Spinal block	Chloroprocaine : Spinal anaesthesia in planned surgical procedure not exceeding 40 minutes – only adults (18 - 65 years old) Levobupivacaine : Intrathecal anaesthesia – only adults (18 years old or older)
Spinal cord compression	Zoledronic acid : Prevention of skeletal related events – only adults (18 years old or older)
Spinal muscular atrophy	Nusinersen : Spinal muscular atrophy 5q – only adults (18 - 65 years old) Risdiplam : 5q spinal muscular atrophy (SMA) – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 - 65 years old)
Spiral computed tomography scan	Iopromide : Spiral computed tomography scan – only adults (18 - 65 years old)
Sprain of ligament	Flurbiprofen : Rheumatoid disease, osteoarthritis, ankylosing spondylitis, musculoskeletal disorders, periarthritis, frozen shoulder, bursitis – only adolescents (12 years - 18 years old) , adults (18 years old or older) Ibuprofen : Muscular pain, sprains, strains, sports injuries – only adolescents (12 years - 18 years old) , adults (18 - 65 years old) Nimesulide : Sprain – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Squamous cell carcinoma of anogenital area	Bleomycin : Squamous cell carcinoma (SCC) of the head and neck, cervix, external genitalia – only adults (18 years old or older)
Squamous cell carcinoma of cervix	Bleomycin : Squamous cell carcinoma (SCC) of the head and neck, cervix, external genitalia – only adults (18 years old or older)
Squamous cell carcinoma of head and neck	Bleomycin : Squamous cell carcinoma (SCC) of the head and neck, cervix, external genitalia – only adults (18 years old or older) Cetuximab : Squamous cell cancer of the head and neck – only adults (18 years old or older) Cis-Diaminedichloroplatinum : Head and neck squamous-cell epithelioma – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Docetaxel : Squamous cell carcinoma of the head and neck – only adults (18 years old or older) Fluorouracil : Squamous cell carcinoma of the head and neck – only adults (18 years old or older) Nivolumab : Squamous Cell Cancer of the Head and Neck (SCCHN) – only adults (18 years old or older) Temoporfin : Head and neck squamous cell carcinoma – only adults (18 years old or older)
Squamous cell carcinoma of skin	Cemiplimab : Metastatic or locally advanced cutaneous squamous cell carcinoma – only adults (18 years old or older)
Squamous non-small cell lung cancer	Afatinib : Non-small cell lung cancer (NSCLC) of squamous histology – only adults (18 years old or older)
Stable angina	Amlodipine : Chronic stable angina pectoris, vasospastic angina – only adults (18 years old or older) Carvedilol : Chronic stable angina pectoris – only adults (18 years old or older) Felodipine : Stable angina pectoris – only adults (18 years old or older) Ivabradine : Chronic stable angina pectoris – only adults (18 years old or older) Nicorandil : Stable angina pectoris – only adults (18 years old or older) Ranolazine : Stable angina pectoris – only adults (18 years old or older) Trimetazidine : Stable angina pectoris – only adults (18 years old or older)
Staphylococcal infectious disease	Rifampicin : Staphylococcal infection – only adults (18 years old or older)
Status epilepticus	Diazepam : Status epilepticus – only elderly (65 years old or older) Diazepam : Status epilepticus – only adults (18 - 65 years old) Lorazepam : Status epilepticus – only elderly (65 years old or older) Lorazepam : Status epilepticus – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) Lorazepam : Status epilepticus – only adults (18 - 65 years old) Phenytoin : Status epilepticus, severe head injury – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Stevens-Johnson syndrome	Methylprednisolone : Stevens-Johnson syndrome – only minors (0 - 18 years old) Methylprednisolone : Stevens-Johnson syndrome – only adults (18 years old or older)
Stomach ache	Hydrotalcite : Stomach ache – only adolescents (12 years - 18 years old) , adults (18 years old or older) Magnesium hydroxide : Stomach discomfort, indigestion, hyperacidity, heartburn, flatulence – only children (1 year - 12 years old) Magnesium hydroxide : Stomach discomfort, indigestion, hyperacidity, heartburn, flatulence – only adolescents (12 years - 18 years old) , adults (18 years old or older) Paracetamol : Pain, fever – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Stomatitis	Benzydamine : Painful oropharyngeal conditions – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Ketoprofen : Irritating and inflammatory conditions of the oral cavity – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Strain	Diethylamine salicylate : Lumbago, fibrositis, sciatica, bruises, strains – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Flurbiprofen : Rheumatoid disease, osteoarthritis, ankylosing spondylitis, musculoskeletal disorders, periarthritis, frozen shoulder, bursitis – only adolescents (12 years - 18 years old) , adults (18 years old or older) Ibuprofen : Muscular pain, sprains, strains, sports injuries – only adolescents (12 years - 18 years old) , adults (18 - 65 years old) Ketoprofen : Painful musculoskeletal conditions caused by trauma, pain of non serious arthritis – only adults (18 years old or older)
Streptococcal infectious disease	Tetracycline : Streptococcal infections – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Streptococcal sore throat	Clarithromycin : Streptococcal pharyngitis and tonsillitis – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Streptococcal tonsillitis	Clarithromycin : Streptococcal pharyngitis and tonsillitis – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Stress bladder incontinence	Duloxetine : Moderate to severe Stress Urinary Incontinence (SUI) – only adults (18 years old or older)
Stress echocardiography using dobutamine	Dobutamine : Dobutamine stress echocardiography – only adults (18 years old or older)
Subacute idiopathic demyelinating polyradiculoneuropathy	Prednisolone : Subacute inflammatory demyelinating polyradiculoneuropathy – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Subacute neuronopathic Gaucher's disease	Imiglucerase : Non-neuronopathic (Type 1) Gaucher disease, chronic neuronopathic (Type 3) Gaucher disease – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Subsequent non-ST segment elevation myocardial infarction	Bivalirudin : Treatment of adult patients with unstable angina/non-ST segment elevation myocardial infarction – only adults (18 years old or older)
Superficial basal cell carcinoma	Fluorouracil : Pre-malignant and malignant skin lesions – only adults (18 years old or older) Imiquimod : Superficial basal cell carcinoma – only adults (18 years old or older)
Superficial mycosis	Isoconazole : Superficial fungal infections of the skin – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Superovulation	Choriogonadotropin alpha : Follicular maturation and luteinisation – women, only adults (18 - 65 years old) Chorionic gonadotrophin (human) : Promotion of controlled superovulation – women, only adults (18 - 65 years old)
Suppressed lactation	Cabergoline : Suppression of physiological lactation – women, only adults (18 - 65 years old)
Supraventricular arrhythmia	Antazoline : Paroxysmal arrhythmias of supraventricular origin – only adults (18 years old or older) Flecainide : Supraventricular arrhythmia, re-entrant atrioventricular node tachycardia, Wolff-Parkinson-White pattern – only elderly (65 years old or older) Flecainide : Supraventricular arrhythmia, re-entrant atrioventricular node tachycardia, Wolff-Parkinson-White pattern – only adolescents (12 years - 18 years old) , adults (18 - 65 years old)
Supraventricular tachycardia	Amiodarone : Tachyarrhythmias – only adults (18 years old or older) Esmolol : Supraventricular tachycardia – only adults (18 years old or older) Landiolol : Supraventricular tachycardia – only adults (18 years old or older) Metoprolol : Supraventricular tachycardia – only adults (18 years old or older) Oxprenolol : Supraventricular tachycardia, atrial fibrillation, ventricular tachycardia – only adults (18 years old or older)
Surgical procedure	Floxacillin : Prophylactic agent during major surgical procedures – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Surgical procedure on eye proper	Acetylcholine : To obtain rapid and complete miosis – only adults (18 years old or older)
Surgical procedure on eye region	Bromfenac : Postoperative ocular inflammation following cataract extraction – only adults (18 years old or older)
Swimmer's ear	Clobetasone : Otitis externa, prurigo nodularis, insect bite reactions – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Erythromycin : Ear infection – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Hydrocortisone : Prurigo nodularis, neurodermatoses, otitis externa, intertrigo, napkin rash – only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Swollen abdomen	Itopride : Functional, non-ulcer dyspepsia, bloating, gastric fullness, discomfort to pain in epigastrium, anorexia, heartburn, nausea – only adults (18 years old or older)
Symptomatic congestive heart failure	Enalapril : Symptomatic congestive heart failure – only adults (18 years old or older) Perindopril : Symptomatic heart failure – only adults (18 years old or older) Ramipril : Symptomatic heart failure – only adults (18 years old or older)
Synovitis	Ketoprofen : Arthritis, musculoskeletal syndromes, dysmenorrhea – only adults (18 years old or older) Prednisolone : Synovitis – only adults (18 years old or older) Triamcinolone : Rheumatoid arthritis, juvenile idiopathic arthritis, osteoarthritis, post-traumatic arthritis, synovitis, tendinitis, bursitis – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Syphilis	Ceftriaxone : Syphilis – only newborns (0 - 40 days old) Ceftriaxone : Syphilis – only infants (40 days - 1 year old) , children (1 year - 12 years old) Ceftriaxone : Syphilis – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Syphilitic gumma	Tetracycline : Syphilis of more than one year's duration – only adolescents (12 years - 18 years old) , adults (18 years old or older)
Systemic infection	Ulinastatin : Severe sepsis – only adults (18 years old or older)
Systemic lupus erythematosus	Anifrolumab : Moderate to severe, active autoantibody-positive systemic lupus erythematosus (SLE) – only adults (18 years old or older) Azathioprine : Auto-immune disorders – only adolescents (12 years - 18 years old) , adults (18 years old or older) Belimumab : Systemic lupus erythematosus (SLE) – only adults (18 - 65 years old) Hydroxychloroquine : Juvenile idiopathic arthritis, discoid and systemic lupus erythematosus – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) Hydroxychloroquine : Rheumatoid arthritis, discoid and systemic lupus erythematosus, sunlight damaged skin – only adults (18 years old or older) Methylprednisolone : Systemic lupus erythematosus – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Prednisolone : Systemic lupus erythematosus – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Systemic mastocytosis with associated clonal haematological non-mast cell lineage disease	Midostaurin : Aggressive systemic mastocytosis, systemic mastocytosis with associated haematological neoplasm, mast cell leukaemia – only adults (18 - 65 years old)
Systemic onset juvenile chronic arthritis	Anakinra : Still's Disease – only adults (18 years old or older) Canacinumab : Still's disease – only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older) Tocilizumab : Systemic juvenile idiopathic arthritis (sJIA) – only children (1 year - 12 years old) , adolescents (12 years - 18 years old)
Systemic sclerosis	Bosentan : Systemic sclerosis – only adults (18 years old or older)

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